Genes, Populações e Doenças

ObjectivesResearchersPublications

Main Researcher: Licínio Manco

The main research focus of Genes, Populations and Diseases group is the assessment of genetic variation across populations, including both normal and disease phenotypes.

The group activity covers important topics in human genetics, including:

  1. genetic basis of complex diseases, including obesity;
  1. molecular basis of haematological conditions, namely red cell enzyme deficiencies, HbF production in adults and venous thrombosis susceptibility.
  1. effect of diseases (such as malaria) on modern patterns of genetic variation;
  2. population genetics studies using Y-chromosome and autosomal variants.

Coordinator

Licínio Manco
Researcher; Group Coordinator
Licínio MancoResearcher; Group Coordinator
  Research group: Genes, Populations and Disease (Group Coordinator)LManco   Institutional Address: Research Centre for Anthropology and Health (CIAS) Department of Life Sciences Email: lmanco@antrop.uc.pt Phone number: +351 239 240 700   Research interests:
  • Genetic basis of human variation, in both normal and disease phenotypes;
  • Genetic basis of complex diseases, including obesity and haematological conditions;
  • Molecular basis of human genetic diseases, with a particular focus on red cell enzyme deficiencies;
  • Population genetic studies using common genetic variation in autosomal and Y-chromosome loci.
  Ongoing Projects: P1: Genetic and environmental determinants of healthy ageing and longevity. P2: Genetic basis of haematological conditions. – Genetics of venous thrombosis (VT) risk. – Fetal haemoglobin (HbF) gene regulation. P3: Study of genetic variants associated with common and morbid obesity. P4: Y-chromosome variation in Portugal: relationships with historical or demographic events and patrilineal surnames. P5: Ancient DNA analyses from human skeletal remains.   Personal URL: https://www.researchgate.net/profile/Licinio_Manco http://orcid.org/0000-0002- 2636-0288

Researchers (PhD)

Celeste Bento
Researcher
Celeste BentoResearcher

 

Research group: Genes, Populations and DiseaseCeleste Bento

Institutional Address:

Hospitais da Universidade de Coimbra
Department of Clinical Hematology
Coimbra, Portugal

Email: celeste.bento@chuc.min-saude.pt

 

Research interests:

  • Hematology
  • Blood
  • Hemoglobinopathies
  • Blood Disorders
  • Erythrocytosis
  • Red Blood Cells
  • Hemoglobin M
  • Abnormal Erythrocytes

Personal URL:

https://independent.academia.edu/CelesteBento

http://orcid.org/0000-0002- 2636-0288

David Albuquerque
Post-Doc Researcher
David AlbuquerquePost-Doc Researcher

Research group: Genes, Populations and Disease

 

Institutional Address:

Research Center for Anthropology and Health (CIAS),
University of Coimbra,

Email: dav.albuquerque@gmail.com

 

Research interests

I am currently interested on the study of the genetic basis of obesity, particularly the following lines:

  • Identify new genetic variants associated with the susceptibility risk to develop an obese phenotype.
  • Identify mutations in the MC4R and LEPR genes associated with monogenic obesity.
  • Examine the methylation levels of several CpG sites.

Overall, I am interested in identifying a genetic profile to predict the obesity susceptibility risk.

 

Personal URL:

CienciaVitae: 8D1D-B84E-E349

http://www.degois.pt/visualizador/curriculum.jsp?key=6209402451024566

http://www.orcid.org/0000-0001- 8899-9020

https://www.researchgate.net/profile/David_Albuquerque

Manuela Alvarez
Assistant Professor
Manuela AlvarezAssistant Professor

 

Research group: Genes, Populations and Disease

 

Institutional Address:

Departamento de Ciências da Vida
Faculdade de Ciências e Tecnologia
Universidade de Coimbra
Calçada Martim de Freitas
3000-456 Coimbra
Portugal

 

Email: 

alvarez@antrop.uc.pt

 

Research interests: 

Genetics of Human Populations, Human Population Dynamics and Evolution.

 

Personal URL

http://www.degois.pt/visualizador/curriculum.jsp?key=5306830375143950

 

Teresa Fidalgo
Researcher
Teresa FidalgoResearcher

 

Research group: Genes, Populations and Disease

 

Research Interest: Mutation analysis; Hematologic Diseases; Human molecular genetic; Next Generation Sequencing

Her major research activities have been in molecular diagnosis of Haemophilia, von Willebrand Disease, thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). She is currently involved in optimisation of these studies and other coagulopathies by Next Generation Sequencing (NGS).

 

Personal URL:

https://www.researchgate.net/profile/Teresa_Fidalgo2

Researchers (Non PhD)

Helena Dias
PhD Student
Helena DiasPhD Student

Research group: Genes, Populations and Disease

Institutional Address: Department of Life Sciences, University of Coimbra  

Email: helenadias_3@hotmail.com

Research interests:

Human Genetics, Human Biology, Genetic basis of complex diseases, Forensic Genetics, Forensic Anthropolgy, Osteology, Skeletal Biology, Age at death estimation, DNA methylation, Ancient DNA, Burned bones, Paleopatology ; Biogeographic ancestry markers

Personal URL:

ResearchGate

 Linkedin 

Collaborators

Ana Paula Arez
Researcher
Ana Paula ArezResearcher
Research group: Genes, Populations and Disease
Ana_Arez
Institutional Address:
Universidade Nova de Lisboa, Instituto de Higiene e Medicina Tropical, Centro de Malária e outras Doenças Tropicais (CMDT)
Phone number: (+351)213652600Extensão: 361
E-mail: aparez@ihmt.unl.pt
Research interests:
Ana Paula Arez works in the area of Health and Biological Sciences, mainly in research related to malaria and other parasitic disease
Cristina Afonso
PhD Student
Cristina AfonsoPhD Student

 

Research group: Genes, Populations and Disease


Institutional Address: Research Centre for Anthropology and Health

Email: capa105@gmail.com

 

Research interests:

  • Ancient DNA
  • Molecular Biology

 

Personal URL:

https://coimbra.academia.edu/CristinaAfonso

https://www.researchgate.net/profile/Cristina_Afonso3/info

 

Janet Pereira
Researcher
Janet PereiraResearcher
Maria Letícia Ribeiro
Researcher
Maria Letícia RibeiroResearcher

Research group: Genes, Populations and Disease

Rui Sá
Researcher
Rui SáResearcher

 

rui sá

Research group: Genes, Populations and Disease

 

Institutional Address: Department of Life Sciences

E-mail: rms@uc.pt

 

Research interests:

BSc in Anthropology from the University of Lisbon, with the specialty of Ethno-Cultural and Biological Anthropology Relations (2003). Holds a Post Gradutate Diploma in Human Evolution at the University of Coimbra (2007) and Master in Evolution and Human Biology also from the University of Coimbra. His Phd was in Biological Anthropology and Ethnoecology at Univeraidade Nova de Lisboa and Cardiff University-UK, having been awarded the title of Doctor Europaeus (2013). His postdoctoral studies were performed on the recently created  HPI-Lab (Laboratory for Infectious Diseases Common to Human and Non Human Primates) in Brno, Czech Republic, belonging to the Faculty of Veterinary Medicine of the University of Veterinary and Pharmaceutical Sciences (2012-2014).

He has experience in Molecular Ecology area and Mastozoology, being expert in Primatology, but also in Parasitology, Conservation Genetics , Phylogeography and Ethnobiology of African primates with emphasis on West Africa and especially in Guinea-Bissau, where he works since 2007. Its research interests relate to Intersectionality between Biology, Ecology, Biodiversity Conservation (and in general of other species), Emerging and neglected infectious diseases, primate aging and longevity,  and ethno-cultural perceptions of wildlife. Methodologically he applies a myriad of comprehensive techniques in his studies; i.e. genetic, parasitological and ethnographic.

 

Ongoing Projects:

Aging and longevity in Coimbra district- ANT/00283

 

Closed Projects:

Development team and scientific laboratory for infectious diseases common to humans and great apes, Czech Grant Agency CZ.1.07/2.3.00/20.0300

Applied landscape genetics to chimpanzee conservation in Guinea-Bissau. United States Fisheries and Wildlife Service. Great Ape Fund, GA 0678.

Guinea-Bissau endangered chimpanzee conservation genetics: Biological Anthropology contribution to biodiversity conservation. PTDC/CS/ANT/099184/2008.

Genetic characterization of a group of chimpanzees (Pan troglodytes verus) from the coastal region of Guinea-Bissau. Portuguese Science and Technology Foundation. SFRH/BD/35797/2007

Chimpanzee distribution and relation with local human communities in coastal area of Guinea-Bissau. POCI/ANT/57434/2004

 

Personal URL:

https://www.researchgate.net/profile/Rui_Sa4/info?ev=prf_info

http://www.degois.pt/visualizador/curriculum.jsp?key=9033764491665827

http://cardiff.academia.edu/RuiSá

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