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Licínio Manco

Research Interests
Genetics of obesity
Y chromosome variation
genetics of hematological conditions
DNA methylation

1991 at present: full-time lab manager/researcher at Laboratory of Human Genetics – Research Centre for Anthropology and Health (CIAS), Department of Life Sciences (former Department of Anthropology), University of Coimbra.

1996 at present: Collaboration with the Molecular Hematology Unit – Department of Hematology, Centro Hospitalar e Universitário de Coimbra (CHUC).


Practical lectures (laboratory or theoretical-practical) in Human Population Genetics at Departamento de Ciências da Vida / Antropologia – Universidade de Coimbra.

Courses, workshops and conferences for students of the University of Coimbra and secondary school teachers in Human and Population Genetics.

Main Publications

Correia Dias H, Cunha E, Corte Real F, Manco L. Challenges and (Un)Certainties for DNAm Age Estimation in Future. Forensic Sciences. 2022; 2(3):601-614. https://doi.org/10.3390/forensicsci2030044

Manco L, Santos R, Rocha C, Relvas L, Bento C, Maia T, Gomes V, Amorim A, Prata MJ. Hb F Levels in β-Thalassemia Carriers and Normal Individuals: Known and Unknown Quantitative Trait Loci in the β-Globin Gene Cluster. 2022; 46(3):168-175. doi: 10.1080/03630269.2022.2070498.

Kirschner M, Heinen IR, Koschmieder S, Manco L, Bento C, Eggermann T, Kurth I, Jost E, Brümmendorf TH, Fuchs R. Novel homozygous nonsense mutation in the P5’N-1 coding gene as an alternative cause for hereditary anemia with basophilic stippling. Clin Case Rep. 2022; 10(3):e05501. doi: 10.1002/ccr3.5501.

Manco L, Dias HC. DNA methylation analysis of ELOVL2 gene using droplet digital PCR for age estimation purposes. Forensic Sci Int. 2022; 333:111206. doi: 10.1016/j.forsciint.2022.111206.

Videira-Silva A, Manco L, Sardinha LB, Fonseca H. Vigorous physical activity: a potential ally in adolescent obesity management. Eur J Sport Sci. 2022 Jan 27:1-10. doi: 10.1080/17461391.2022.2035437.

Correia Dias H, Manco L, Corte Real F, Cunha E. A Blood-Bone-Tooth Model for Age Prediction in Forensic Contexts. Biology (Basel). 2021; 10(12):1312. doi: 10.3390/biology10121312.

Correia Dias H, Corte-Real F, Cunha E, Manco L. DNA methylation age estimation from human bone and teeth. Australian Journal of Forensic Sciences. 2022; 54:2, 163-176. DOI: 10.1080/00450618.2020.1805011

Correia Dias H, Cunha E, Corte Real F, Manco L. Age prediction in living: Forensic epigenetic age estimation based on blood samples. Leg Med (Tokyo). 2020; 47:101763. doi: 10.1016/j.legalmed.2020.101763.

Manco L, Bento C, Relvas L, Cunha E, Pereira J, Moreira V, Alvarez M, Maia T, Ribeiro ML. Multi-Locus Models to Address Hb F Variability in Portuguese β-Thalassemia Carriers. Hemoglobin 2020; 44(2):113-117. https://doi.org/10.1080/03630269.2020.1753766

Manco L, Machado-Rodrigues AM, Padez C. Association study of common functional genetic polymorphisms in SLC6A4 (5-HTT) and MAOA genes with obesity in portuguese children. Archives of Physiology and Biochemistry. 2022; 128(6):1510-1515. https://doi.org/10.1080/13813455.2020.1779312

Correia Dias H, Cordeiro C, Pereira J, Pinto C, Real FC, Cunha E, Manco L. DNA methylation age estimation in blood samples of living and deceased individuals using a multiplex SNaPshot assay. Forensic Science International. 2020; 311:110267. https://doi.org/10.1016/j.forsciint.2020.110267

Correia Dias H, Cordeiro C, Corte Real F, Cunha E, Manco Age Estimation Based on DNA Methylation Using Blood Samples From Deceased Individuals. J Forensic Sci. 2020; 65(2):465-470. doi: 10.1111/1556-4029.14185.

Manco L, Pinho S, Albuquerque D, Machado-Rodrigues AM, Padez C. Physical activity and the association between the FTO rs9939609 polymorphism and obesity in Portuguese children aged 3 to 11 years. Am J Hum Biol. 2019; 31(6):e23312. doi: 10.1002/ajhb.23312.

Palmeira L, Cunha M, Padez C, Alvarez M, Pinto-Gouveia J, Manco Association study of variants in genes FTO, SLC6A4, DRD2, BDNF and GHRL with binge eating disorder (BED) in Portuguese women. Psychiatry Res. 2019; 273:309-311. doi: 10.1016/j.psychres.2019.01.047.

Pinho S, Padez C, Manco L. High AMY1 copy number protects against obesity in Portuguese young adults. Ann Hum Biol. 2018; 45(5):435-439. doi: 10.1080/03014460.2018.1490452.

Manco L, Silva C, Fidalgo T, Martinho P, Sarmento AB, Ribeiro ML. Venous thromboembolism risk associated with ABO, F11 and FGG loci. Blood Coagul Fibrinolysis. 2018; 29(6):528-532. doi: 10.1097/MBC.0000000000000753.

Manco L, Albuquerque J, Sousa MF, Martiniano R, de Oliveira RC, Marques S, Gomes V, Amorim A, Alvarez L, Prata MJ. The Eastern side of the Westernmost Europeans: Insights from subclades within Y-chromosome haplogroup J-M304. American Journal of Human Biology. 2018; 30(2): e23082. doi: 10.1002/ajhb.23082.

Albuquerque D, González LM, Ferrer FG, Bruna M, Sánchez C, Benito GM, Rodríguez-López R, Manco L. Association study of six single nucleotide polymorphisms with obesity in two independent Iberian samples. Meta Gene. 2018; 17:17-22. https://doi.org/10.1016/j.mgene.2018.04.006

Fidalgo T, Martinho P, Pinto CS, Oliveira AC, Salvado R, Borràs N, Coucelo M, Manco L, Maia T, Mendes MJ, Del Orbe Barreto R, Corrales I, Vidal F, Ribeiro ML. Combined study of ADAMTS13 and complement genes in the diagnosis of thrombotic microangiopathies using next-generation sequencing. Res Pract Thromb Haemost. 2017; 1(1):69-80.

Albuquerque D, Nóbrega C, Manco L, Padez C. The contribution of genetics and environment to obesity. British Medical Bulletin. 2017; 123(1):159-173. doi: 10.1093/bmb/ldx022.

Martiniano R, Cassidy LM, Ó’Maoldúin R, McLaughlin R, Silva NM, Manco L, Fidalgo D, Pereira T, Coelho MJ, Serra M, Burger J, Parreira R, Moran E, Valera AC, Porfirio E, Boaventura R, Silva AM, Bradley DG. The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods. PLoS Genetics. 2017; 13(7):e1006852.

Manco L, Soares A, Wasterlain SN. Association of 5-HTTLPR genotypes with antisocial behavior in response to childhood environment: A study in young adults of Portuguese origin. Psychiatry Research. 2018; 262:325-327. doi: 10.1016/j.psychres.2017.01.001

Jaouani M, Manco L, Kalai M, Chaouch L, Douzi K, Silva A, Macedo S, Darragi I, Boudriga I, Chaouachi D, Fitouri Z, Van Wijk R, Ribeiro ML, Abbes S. Molecular basis of pyruvate kinase deficiency among Tunisians: description of new mutations affecting coding and noncoding regions in the PKLR gene. Int J Lab Hematol. 2017; 39(2):223-231. doi: 10.1111/ijlh.12610.

Albuquerque D, Manco L, González LM, Gervasini G, Benito GM, González JR, Rodríguez-López R. Polymorphisms in the SNRPN gene are associated with obesity susceptibility in a Spanish population. Journal of Gene Medicine 2017; 19(5). doi: 10.1002/jgm.2956.

Research Projects

Assessing the genetic basis of common and severe forms of obesity

Analysis of Y-chromosome haplogroup subclades in the Portuguese population

Human age prediction based on DNA methylation analysis

Identifying genetic variants associated with HbF variation in hematological conditions