{"id":1889,"date":"2022-06-13T11:52:58","date_gmt":"2022-06-13T10:52:58","guid":{"rendered":"https:\/\/cias.uc.pt\/investigacao\/grupos-de-investigacao\/genes-populacoes-e-doencas\/projetos\/"},"modified":"2023-03-05T18:24:04","modified_gmt":"2023-03-05T18:24:04","slug":"projetos","status":"publish","type":"page","link":"https:\/\/cias.uc.pt\/pt-pt\/investigacao\/grupos-de-investigacao\/genes-populacoes-e-doencas\/projetos\/","title":{"rendered":"Projetos"},"content":{"rendered":"<div class=\"pt-cv-wrapper et_smooth_scroll_disabled\"><div class=\"pt-cv-view pt-cv-collapsible pt-cv-pgloadmore pt-cv-reused custom_projects\" id=\"pt-cv-view-9b5817cb3q\"><div data-id=\"pt-cv-page-1\" class=\"pt-cv-page\" data-cvc=\"1\"><div class=\"panel-group\" id=\"c993fd7aod\"><div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"7877\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#501e668kug\" href='https:\/\/cias.uc.pt\/pt-pt\/projetos\/prev-hbs-prevalencia-de-hemoglobina-s-em-cabo-verde-e-sensibilizacao-para-o-diagnostico-precoce-de-doenca-falciforme-data-de-inicio-e-termino-2025\/' onclick='event.preventDefault()'>\r\n\t\tPREV-HbS Preval\u00eancia de Hemoglobina S em Cabo Verde e Sensibiliza\u00e7\u00e3o para o Diagn\u00f3stico Precoce de Doen\u00e7a Falciforme (Data de in\u00edcio e t\u00e9rmino: 2025)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"501e668kug\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Data de in\u00edcio e t\u00e9rmino: <\/strong>Julho a Outubro de 2025<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Resumo:<\/strong>\u00a0A preval\u00eancia de hemoglobina S (Hb S) em Cabo Verde \u00e9 uma realidade que, associada \u00e0 falta de diagn\u00f3stico e aconselhamento gen\u00e9tico contribui para o elevado risco de nascimento de crian\u00e7as com doen\u00e7a falciforme. O projeto PREV-HbS visa implementar um programa de estudo da preval\u00eancia de Hb S direcionado a mulheres gr\u00e1vidas e em idade f\u00e9rtil, com idades compreendidas entre os 16 e os 49 anos, identificando portadoras e permitindo interven\u00e7\u00f5es precoces; capacitar profissionais de sa\u00fade locais \u2013 incluindo m\u00e9dicos, enfermeiros e t\u00e9cnicos laboratoriais \u2013 para o diagn\u00f3stico precoce e o seguimento cl\u00ednico da doen\u00e7a falciforme; promover a literacia gen\u00e9tica e o aconselhamento reprodutivo, reduzindo o risco de transmiss\u00e3o e melhorando a qualidade de vida das fam\u00edlias.<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Coordenador:\u00a0<\/strong>Celeste Bento<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Participantes: <\/strong>Luis Relvas, Linette Fernandes, Concei\u00e7\u00e3o Pinto, Ant\u00f3nio Maximiano Fernandes, Pamela Borges, Guilherme \u01eaueiroz, Lic\u00ednio Manco, Joana Ramos<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Institui\u00e7\u00f5es parceiras: <\/strong>ALUA \u2013 Alian\u00e7a Lus\u00f3fona de Especialistas para a Doen\u00e7a Falciforme (Coordena\u00e7\u00e3o); Hospital Universit\u00e1rio Agostinho Neto, Praia, Santiago; Hospital Dr. Baptista de Sousa, Mindelo, S\u00e3o Vicente; Laborat\u00f3rio Bioanalitica Lda; Centro de Investiga\u00e7\u00e3o em Antropologia e Sa\u00fade (CIAS); Unidade Funcional de Hematologia Molecular; Associa\u00e7\u00e3o Portuguesa de Pais e Doentes com Hemoglobinopatias (APPDH).<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Apoio financeiro:<\/strong>\u00a0Programa &#8220;Sa\u00fade nos Junta&#8221; da Secretaria Geral do Minist\u00e9rio da Sa\u00fade de Portugal<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"4998\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#10b107c0dg\" href='https:\/\/cias.uc.pt\/pt-pt\/projetos\/em-curso\/empowering-healthy-lifestyle-behaviour-through-personalised-intervention-portfolios-to-prevent-and-control-obesity-during-vulnerable-stages-of-life-healthyw8\/' onclick='event.preventDefault()'>\r\n\t\tHealthyW8 &#8211; Empowering healthy lifestyle behaviour through personalised intervention portfolios to prevent and control obesity during vulnerable stages of life (Data de in\u00edcio e t\u00e9rmino: 04\/2023 \u2013 03\/2028)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"10b107c0dg\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><\/p><p>O objetivo do HealthyW8 \u00e9 aumentar a efic\u00e1cia dos esfor\u00e7os e investimentos atuais e futuros em iniciativas de preven\u00e7\u00e3o da obesidade em toda a Europa. As iniciativas pol\u00edticas e pr\u00e1ticas de preven\u00e7\u00e3o da obesidade t\u00eam frequentemente um impacto marginal. O HealthyW8 abordar\u00e1 estas defici\u00eancias, desenvolvendo iterativamente, em colabora\u00e7\u00e3o com partes interessadas, um recomendador de estilo de vida saud\u00e1vel baseado em tecnologia digital para interven\u00e7\u00f5es e ferramentas personalizadas e baseadas em evid\u00eancias, incluindo um g\u00e9meo digital humano para preencher a lacuna entre a ci\u00eancia, os intervenientes sociais e partes interessadas (por exemplo, profissionais de sa\u00fade, ind\u00fastrias alimentares, formuladores de pol\u00edticas) e cidad\u00e3os da UE.\u00a0<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Coordenador: <\/strong>Torsten Bohn, Luxembourg Institute of Health\u00a0<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Participantes (CIAS): <\/strong>Daniela Rodrigues; Helena Nogueira; Lic\u00ednio Manco; Maria-Raquel G. Silva<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Institui\u00e7\u00f5es parceiras:<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li>Luxembourg Institute Of Health\u00a0\u2013 LIH (998331858)\u00a0&#8211;\u00a0COORDENADOR<\/li>\n\n\n\n<li>Luxembourg Institute Of Science And Technology\u00a0\u2013 LIST (934320200)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>NIUM\u00a0&#8211;\u00a0(898185954)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Deutsches Forschungszentrum Fur Kunstliche Intelligenz GMBH\u00a0\u2013 DFKI (999607602)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>VIRTECH OOD\u00a0&#8211;\u00a0(997240705)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Leibniz-Institut Fur Praventionsforschung Und Epidemiologie &#8211; BIPS GMBH\u00a0&#8211; LEIBNIZ-Institut Fur Praventionsforschung Und Epidemiologie &#8211; BIPS GMBH (962342336)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>SPORA SINERGIES SCCL\u00a0&#8211;\u00a0(986594082)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Centre De Recerca En Economia I Desenvolupament Agroalimentari-UPC-IRTA\u00a0\u2013 CREDA (986340815)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Universita Degli Studi Di Scienze Gastronomiche\u00a0&#8211; University Of Gastronomic Sciences (949553468)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Consiglio Nazionale Delle Ricerche\u00a0\u2013 CNR (999979500)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Centro De Investigacion Y Tecnologia Agroalimentaria De Aragon\u00a0&#8211; CITA\u00a0(997262142)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Universidade De Evora\u00a0(998269196)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Fundacio Institut D&#8217;investigacio Sanitaria Illes Balears\u00a0&#8211; Foundation Health Research Institute Of The Balearic Islands (974340460)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>IRCCS Azienda Ospedaliero- Universitaria Di Bologna\u00a0&#8211; IRCCS AOU BO (991016991)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Danmarks Tekniske Universitet\u00a0&#8211; Technical University Of Denmark DTU (999990655)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Universiteit Twente\u00a0(999900833)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Universidade De Coimbra\u00a0 (997826391)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Regional Cluster North-East\u00a0&#8211;\u00a0(935248296)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Technische Universiteit Eindhoven\u00a0&#8211; TU\/e (999977269)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>MEDEA SRL\u00a0&#8211;\u00a0(951976140)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Asociatia Euro Atlantic Diplomacy Society\u00a0&#8211;\u00a0(890633243)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Stichting European Nutrition For Health Alliance\u00a0&#8211; European Nutrition For Health Alliance (883383269)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>KNEIA SL\u00a0&#8211;\u00a0(936881582)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n\n\n\n<li>Europese Federatie Van Verenigingen Van Dietisten\u00a0&#8211; The European Federation Of The Associations Of Dietitians EFAD (947201412)\u00a0&#8211;\u00a0BENEFICI\u00c1RIO<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Financiamento:<\/strong><strong>\u00a0<\/strong>European Commission, HORIZON Programme &#8211; 10.000.000\u20ac<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Refer\u00eancia: <\/strong>101080645<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"6017\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#6a8b186u98\" href='https:\/\/cias.uc.pt\/pt-pt\/projects\/a-study-of-genetic-variants-associated-with-fetal-hemoglobin-hbf-levels-in-the-population-of-s-tome-and-principe-duration-2023-2024\/' onclick='event.preventDefault()'>\r\n\t\tA study of genetic variants associated with fetal hemoglobin (HbF) levels in the population of S. Tom\u00e9 and Pr\u00edncipe (Duration: 2023-2024)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"6a8b186u98\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><strong>Duration:<\/strong>\u00a02023 \u2013 2024<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong> To evaluate the association of genetic variants at the HBB gene cluster, BCL11A gene, and HMIP region ((HBS1L-MYB intergenic polymorphisms) with HbF levels in Hemoglobin S carriers and in normal individuals of S\u00e3o Tom\u00e9 e Pr\u00edncipe.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coordinator:<\/strong> Lic\u00ednio Manco (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Participants:<\/strong> Lic\u00ednio Manco (CIAS), Celeste Bento (CIAS), Afonso Morais (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Financial support: <\/strong>CIAS<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"4992\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#767dc55rx2\" href='https:\/\/cias.uc.pt\/pt-pt\/projetos\/portadores-de-hemoglobina-s-em-sao-tome-e-principe-um-estudo-de-prevalencia-em-mulheres-em-idade-fertil-data-de-inicio-e-termino-01-2023-07-2023\/' onclick='event.preventDefault()'>\r\n\t\tPortadores de Hemoglobina S em S\u00e3o Tom\u00e9 e Pr\u00edncipe: um estudo de preval\u00eancia em mulheres em idade f\u00e9rtil (Data de in\u00edcio e t\u00e9rmino: 01\/2023 \u2013 07\/2023)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"767dc55rx2\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Resumo:<\/strong> Este projeto tem como objetivo principal estimar a preval\u00eancia de portadores de HbS em S\u00e3o Tom\u00e9 e Pr\u00edncipe. Os objetivos secund\u00e1rios s\u00e3o:\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 caracterizar s\u00f3cio demograficamente os portadores de HbS no pa\u00eds; conhecer a distribui\u00e7\u00e3o geogr\u00e1fica dos portadores de HbS; avaliar a literacia em drepanocitose nos participantes e seus determinantes sociodemogr\u00e1ficos; e estimar a preval\u00eancia de mulheres em idade f\u00e9rtil com homozigotia (HbSS) ou com combina\u00e7\u00f5es de HbS com outras variantes da hemoglobina.<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Coordenador<\/strong>: Celeste Bento (CIAS)<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Participantes:<\/strong> Guilherme Queiroz (CIAS), Celdidy Monteiro, Lic\u00ednio Manco (CIAS), Luis Relvas, Maria de Jesus Trovoada<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Institui\u00e7\u00f5es parceiras:<\/strong> Centro de Investiga\u00e7\u00e3o em Antropologia e Sa\u00fade (CIAS), Universidade de Coimbra, Portugal; Laboratorio de Eritropatologia, Unidade Funcional de Hematologia Molecular, Servi\u00e7o de Hematologia Cl\u00ednica, Centro Hospitalar e Universit\u00e1rio de Coimbra, Portugal; Associa\u00e7\u00e3o Portuguesa de Pais e Doentes com Hemoglobinopatias (APPDH); Unidade de Sa\u00fade P\u00fablica do ACES Baixo Vouga, Administra\u00e7\u00e3o Regional de Sa\u00fade do Centro, Portugal; Associa\u00e7\u00e3o Filhos da Meia Lua Vermelha (AFMLV), S\u00e3o Tom\u00e9 e Pr\u00edncipe; Hospital Dr. Ayres de Menezes; Centro Nacional de Endemias S. Tom\u00e9 e Pr\u00edncipe (CNE).<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Apoio financeiro:<\/strong> Centro de Investiga\u00e7\u00e3o em Antropologia e Sa\u00fade (CIAS), Universidade de Coimbra, e Associa\u00e7\u00e3o Portuguesa de Pais e Doentes com Hemoglobinopatias (APPDH).<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"1465\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#ca73354cp2\" href='https:\/\/cias.uc.pt\/pt-pt\/projects\/genetic-basis-of-haematological-conditions\/' onclick='event.preventDefault()'>\r\n\t\tGenetic basis of haematological conditions (Duration:\u00a02018\u20132025)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"ca73354cp2\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><strong>Duration:<\/strong>\u00a02018 \u2013 2025<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract: <\/strong>The aim of the project is the molecular characterization of genetic blood disorders in patients with haemoglobinopathies, red blood cell enzyme defects, venous and arterial thrombosis, haemorragic diseases, congenital erythrocytosis and increased percentages of HbF, searching for genetic variants associated or potentially involved in these clinical phenotypes. This project is conducted in collaboration with the Haematology Service of Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coordinator (PI):&nbsp;<\/strong>Lic\u00ednio Manco (CIAS), Celeste Bento (CIAS), Teresa Fidalgo (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Participants:<\/strong>&nbsp;Lic\u00ednio Manco (CIAS), Celeste Bento (CIAS), Teresa Fidalgo (CIAS), Janet Pereira, Lu\u00eds Relvas, Maria Let\u00edcia Ribeiro (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Financial support:&nbsp;<\/strong><em>Forum hematologico<\/em>&nbsp;(Servi\u00e7o de Hematologia Cl\u00ednica \u2013 CHUC); FCT-CIAS: UID\/ANT\/00283\/2019 (Portugal)<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"5694\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#7271292eqr\" href='https:\/\/cias.uc.pt\/pt-pt\/projetos\/variabilidade-do-cromossoma-y-em-portugal-relacoes-com-eventos-historicos-e-demograficos-data-de-inicio-e-termino-2018-2023\/' onclick='event.preventDefault()'>\r\n\t\tVariabilidade do cromossoma Y em Portugal: rela\u00e7\u00f5es com eventos hist\u00f3ricos e demogr\u00e1ficos (Data de in\u00edcio e t\u00e9rmino: 2018-2023)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"7271292eqr\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Data de in\u00edcio e t\u00e9rmino:<\/strong>\u00a02018 \u2013 2023<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Resumo:<\/strong> Este projeto tem por objetivo identificar linhagens paternas espec\u00edficas que possam ter significado hist\u00f3rico ou demogr\u00e1fico no territ\u00f3rio portugu\u00eas. Em Portugal, as sub-linhagens de alguns haplogrupos comuns do cromossoma Y continuam por identificar, incluindo o haplogrupo do cromossoma Y mais frequente, R1b-M269. A an\u00e1lise de sub-linhagens nestes haplogrupos, pode possibilitar identificar poss\u00edveis ramos desconhecidos, com especial interesse para os movimentos hist\u00f3ricos ou demogr\u00e1ficos ocorridos no territ\u00f3rio e poder\u00e1 ser tamb\u00e9m \u00fatil em gen\u00e9tica forense.<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Coordenador: <\/strong>Lic\u00ednio Manco (CIAS)<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Participantes:<\/strong>\u00a0Lic\u00ednio Manco (CIAS), F\u00e1bio Nunes (CIAS), Selsabil Bouabdallah, Diana Alves<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Apoio Financeiro: <\/strong>FCT, CIAS<\/p>\n\n<p class=\"wp-block-paragraph\"><\/p><p><strong>Refer\u00eancia:<\/strong> UID\/ANT\/00283\/2019<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"1467\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#56a28344qr\" href='https:\/\/cias.uc.pt\/pt-pt\/projects\/the-influence-of-genes-variability-of-the-central-nervous-system-related-toobesity-on-the-establishment-and-evolution-of-eating-disorders\/' onclick='event.preventDefault()'>\r\n\t\tThe influence of genes variability of the central nervous system related to obesity on the establishment and evolution of eating disorders (Duration:\u00a02018\u20132020)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"56a28344qr\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><strong>Duration:<\/strong>&nbsp;2018 \u2013 2020<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong> Several studies have been done to determine which genes related with the Central Nervous System (CNS) could be involved in obesity. These studies have managed to point out a series of relevant genes such as: FTO, MC4R, BDNF, NEGR1, TFAP2B, etc. However, none of these loci have been studied in the field of eating disorders, whose incidence continues increasing among young women, adolescents and even girls. It does not seem far-fetched to think that if there are alterations in these genes that can lead to a change in behavior (e.g. anxiety, hyperphagia, etc.) that leads to obesity, these same alterations could lead to an eating disorder (whether anorexia, bulimia or disorder by binge); especially if certain additional psychopathological features or certain sociocultural environments coexist. In a previous study we have identified some of these genes suggesting that they can play a role in personality traits of patients with eating disorders. The main aim of this study is to analyze 159 tag-SNPs (variants that represent the variability of a gene) located in 15 CNS genes previously related to obesity among a sample of 400 patients with eating disorders and 400 controls. This case-control study will be performed to analyze if there are an association between these genes and the risk of eating disorders as well as with psychopathological parameters. The determination of genetic profiles with direct influence on the implantation or evolution of eating disorders would allow us to identify early risk patients, thus helping to adopt the appropriate preventive or therapeutic measures.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coordinator (PI):<\/strong>&nbsp;Guillermo Gervasini Rodr\u00edguez (Universidad de Extremadura, Spain)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Participants:<\/strong>&nbsp;David Albuquerque (CIAS), Juan Antonio Carillo Norte (Universidad de Extremadura), Angustias Garcia Herraiz (Unidad de Salud Mental II, Unidad de Trastornos Alimentarios, Servicio Extreme\u00f1o de Salud)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Finantial support:<\/strong>&nbsp;Fundaci\u00f3n Alicia Koplowitz (Spain)<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"1472\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#0ebf3d0kl8\" href='https:\/\/cias.uc.pt\/pt-pt\/projects\/integrating-human-omics-data-for-discovering-common-susceptibility-polygenic-profiles-for-obesity\/' onclick='event.preventDefault()'>\r\n\t\tIntegrating human omics data for discovering common susceptibility polygenic profiles for obesity (Duration:\u00a02017-2019)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"0ebf3d0kl8\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><strong>Duration:<\/strong>&nbsp;2017-2019<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract: <\/strong>The main objective of this study is to describe low frequency alleles and copy number variations (CNVs) associated with higher obesity susceptibility risk, as it has not been previously detected, neither with GWAS nor with indirect studies based on their results. We intend to generate genomic data of great potential via massive sequencing technology (NGS), combined with an exhaustive patient selection and the usage of the information stored in eQTL data bases. These results will lead to a second strategy in obesity research by metabolomic and proteomic studies, redefining and widening the \u201coverweight\u201d concept and making it possible to identify markers that will optimize clinical management. All the clinical and phenotypical information of the patients, their family history and the information obtained by genomic technologies, altogether, will be incorporated into new tools capable of managing all the information and cross it with the biological systems that have already been associated with obesity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coordinator (PI):&nbsp;<\/strong>Raquel Rodr\u00edguez-L\u00f3pez (HUGV)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Participants:&nbsp;<\/strong>David dos Santos Albuquerque (CIAS), Concepci\u00f3n Cerda Mico (HUGV), Goitzane Marcaida Benito (HUGV), CL\u00e9vio Rodr\u00edguez N\u00f3brega (Universidade de Algarve), Carola Guzman Lujan (HUGV), Marcos Bruna Esteban (HUGV), Maria Nieves Prieto Colodrero (HUGV), Laura Gandia Artides (HUGV),&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Financial support:&nbsp;<\/strong>Instituto de Salud Carlos III (Spain)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reference:<\/strong>&nbsp;17PI1551<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"1469\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#966c563gyz\" href='https:\/\/cias.uc.pt\/pt-pt\/projects\/age-estimation-based-in-dna-methylation\/' onclick='event.preventDefault()'>\r\n\t\tAge estimation based in DNA methylation (Duration:\u00a02017\u20132025)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"966c563gyz\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><strong>Duration:<\/strong>\u00a02017 \u2013 2025<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract: <\/strong>DNA methylation levels in CpG sites of several genes emerged in last years for age estimation purposes because of its potential application in forensic genetics. The goal of this project is to develop age prediction models in biological samples of living and deceased individuals based in CpG methylation ratios of age-associated genes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coordinator (PI):&nbsp;<\/strong>Lic\u00ednio Manco<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Participants:<\/strong>&nbsp;Helena Correia Dias (CIAS), Eug\u00e9nia Cunha (DCV; INML), Francisco Corte Real (FMUC;INML) Lic\u00ednio Manco (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Financial support:\u00a0<\/strong>Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia, CIAS <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reference: <\/strong>SFRH\/BD\/117022\/2016 (Helena C. Dias)<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div>\n<div class=\"panel panel-default pt-cv-content-item pt-cv-1-col\"  data-pid=\"1474\">\r\n<div class=\"panel-heading pt-cv-title\">\r\n    <a class=\"panel-title\" data-toggle=\"cvcollapse\" data-parent=\"#c993fd7aod\" data-target=\"#936eb2bzed\" href='https:\/\/cias.uc.pt\/pt-pt\/projects\/genetic-and-environmental-determinants-of-healthy-ageing-and-longevity-in-the-population-of-central-portugal\/' onclick='event.preventDefault()'>\r\n\t\tGenetic and environmental determinants of healthy ageing and longevity in the population of central Portugal (Duration:\u00a02016\u20132023)\t<\/a>\r\n\t<span class=\"pull-right clickable panel-collapsed\"><i class=\"glyphicon glyphicon-plus\"><\/i><\/span><\/div>\r\n<div id=\"936eb2bzed\" class=\"panel-collapse collapse \">\r\n\t<div class=\"panel-body\">\r\n\t\t<div class=\"pt-cv-content\">\n<p class=\"wp-block-paragraph\"><strong>Duration:<\/strong>&nbsp;2016 \u2013 2023<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong> The aim of this project is to screen several cohorts of elderly people from different natural and social environments in order to define local healthy phenotypes by gender and culture, and to identify the determinants of health that can affect their development including: i) lifestyle; ii) both natural and built environmental factors; and iii) genetic and epigenetic backgrounds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Coordinator (PI):&nbsp;<\/strong>Manuela Alvarez (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Participants:<\/strong>&nbsp;Manuela Alvarez (CIAS), Tiago Sousa (CIAS), Lic\u00ednio Manco (CIAS)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Financial support:&nbsp;<\/strong>FCT-CIAS: UID\/ANT\/00283\/2019 (Portugal)<\/p>\n<\/div>\t<\/div>\r\n<\/div><\/div><\/div><\/div><\/div>\n<div class=\"text-center pt-cv-pagination-wrapper\"><a href='https:\/\/cias.uc.pt\/pt-pt\/wp-json\/wp\/v2\/pages\/1889\/?_page=2' onclick='event.preventDefault()' class=\"pt-cv-more btn btn-primary btn-sm\" data-totalpages=\"2\" data-nextpages=\"2\" data-sid=\"9b5817cb3q\" data-unid=\"444f0e078ea2cee5444529d64011f25b\" data-isblock=\"\" data-postid=\"\">More <span class=\"caret\"><\/span><\/a><img loading=\"lazy\" decoding=\"async\" width=\"15\" height=\"15\" class=\"pt-cv-spinner\" alt=\"Loading...\" src=\"data:image\/gif;base64,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\" \/><div class=\"clear pt-cv-clear-pagination\"><\/div><\/div><\/div>\t\t\t<style type=\"text\/css\" id=\"pt-cv-inline-style-bb0a5aazkf\">#pt-cv-view-9b5817cb3q .pt-cv-readmore  { color: #ffffff !important; }\n#pt-cv-view-9b5817cb3q .pt-cv-readmore:hover  { color: #ffffff !important; }<\/style>\r\n\t\t\t\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":318,"parent":1876,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1889","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Projetos Genes, Popula\u00e7\u00f5es e Doen\u00e7as - CIAS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cias.uc.pt\/pt-pt\/investigacao\/grupos-de-investigacao\/genes-populacoes-e-doencas\/projetos\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projetos Genes, Popula\u00e7\u00f5es e Doen\u00e7as - CIAS\" \/>\n<meta property=\"og:site_name\" content=\"CIAS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CIASUC\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-05T18:24:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cias.uc.pt\/wp-content\/uploads\/2022\/06\/Genes-Populations-and-Diseases-bg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1277\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@cias_uc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cias.uc.pt\\\/pt-pt\\\/investigacao\\\/grupos-de-investigacao\\\/genes-populacoes-e-doencas\\\/projetos\\\/\",\"url\":\"https:\\\/\\\/cias.uc.pt\\\/pt-pt\\\/investigacao\\\/grupos-de-investigacao\\\/genes-populacoes-e-doencas\\\/projetos\\\/\",\"name\":\"Projetos Genes, Popula\u00e7\u00f5es e Doen\u00e7as - 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