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Teresa Fidalgo

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His entire career has been devoted to the implementation and improvement of studies integrating a routine laboratory (screening and specific coagulation tests), as well as in the laboratory for genetic studies of congenital coagulopathies. Her main research activities have been the molecular diagnosis of haemophilia, von Willebrand’s disease, thrombotic thrombocytopenic purpura (TTP) and haemolytic uremic syndrome (HUS). As coordinator of the UFHM, she implemented molecular studies by Next Generation Sequencing (NGS), which allowed this approach 3 diagnostic areas Erythropathology, Thrombosis and Haemostasis, Microangiopathies and Haemato-Oncology.

The UFHM laboratory is considered a reference centre in clinical-laboratory studies that it investigates and receives samples from all over the country.

Teaching

Professor of Molecular Pathology at Escola Superior de Tecnologias Saúde de Coimbra (ESTESC) (2000 -2015)

Coordinator of courses – Thrombosis and Haemostasis; Molecular Biology – in the scope of Haematology “Sabatinas”

Coordination of curricular internships in laboratory contexts for interns of Haematology, Clinical Pathology and Medical Genetics

Coordination of scientific internships of Graduation and Master’s degrees in collaboration with the UC and UA
Main Publications

Bárbara Marques, Teresa Fidalgo, et al. The challenging management of acute thrombotic microangiopathy in pregnancy. Acta Haematologica, 2022, DOI:10.1159/000527553

Pascual, C, Nieto, JM, Fidalgo, T, et al. Multicentric evaluation of the new HemosIL Acustar® chemiluminescence ADAMTS13 activity assay. Int J Lab Hematol. 2020; 00: 1– 9.

Moreira Fonseca N, Cardoso F, Monteiro M, Fidalgo T et al. A case of bortezomib-associated thrombotic microangiopathy in a multiple myeloma patient. Journal of Onco-Nephrology. 2020;4(1-2):46-51.

Fidalgo T and Ribeiro ML. Added Value of Next-Generation Sequencing for Haemostasis Diagnosis. Thromb Haemost Res. 2017; 1(2): 1007.

Fidalgo T, Martinho P, Pinto CS, Oliveira AC, Salvado R, Borràs N, Coucelo M, Manco L, Maia T, Mendes MJ, Del Orbe Barreto R, Corrales I, Vidal F, Ribeiro ML. Combined study of ADAMTS13 and complement genes in the diagnosis of thrombotic microangiopathies using next-generation sequencing. Res Pract Thromb Haemost. 2017 Jun 23;1(1):69-80. doi: 10.1002/rth2.12016.

Fidalgo T, Salvado R, Corrales I et al. (2016) Genotype-phenotype correlation in a cohort of Portuguese patients comprising the entire spectrum of VWD types: impact of NGS. Thromb Haemost 2016; 116: 17–31: doi. org/ 10.1160/TH15-07-0604

Fidalgo, T., Ferreira, G., Oliveira, A. C., Silva Pinto, C., Martinho, P., Mendes, M. J., Duarte, M., Salvado, R. and Ribeiro, M. L. (2017), Acquired von Willebrand syndrome in haematologic malignancies – how the clinical-laboratory correlation improves a challenging diagnosis – a case series. Haemophilia. doi:10.1111/hae.13243

Fidalgo, T., Oliveira, A., Silva Pinto, C., Martinho, P., Ferreira, G., Salvado, R., Sevivas, T., Catarino, C. and Ribeiro, M. L. (2017), VWF collagen (types III and VI)-binding defects in a cohort of type 2M VWD patients – a strategy for improvement of a challenging diagnosis. Haemophilia, 23: e143–e147. doi:10.1111/hae.13156

Fidalgo T, Martinho P, Salvado R, Manco L, Oliveira AC, Pinto CS, Gonçalves E, Marques D, Sevivas T, Martins N, Ribeiro ML. Familial thrombotic risk based on the genetic background of Protein C Deficiency in a Portuguese Study. Eur J Haematol. 2014 Dec 22. doi: 10.1111/ejh.12488

Silva Pinto C, Fidalgo T, Salvado R, Marques D, Gonçalves E, Martinho P, Markoff A, Martins N, Letícia Ribeiro M. Molecular diagnosis of haemophilia A at Centro Hospitalar de Coimbra in Portugal: study of 103 families-15 new mutations. Haemophilia. 2012 Jan;18(1):129-38.

Relvas M, Tavares I, Fidalgo T, Mendonça L, Coentrão L. Reviewing thrombotic thrombocytopenic purpura diagnosis and treatment in a Portuguese hospital. Eur J Intern Med. 2020 Jan; 71: 95-97. doi: 10.1016/j.ejim.2019.11.004. Epub 2019 Nov 14. PMID: 31735543.

Marini SC, Carda P, Guilherme R, Pinto CS, Fidalgo T, Ribeiro ML. Atypical hemolytic – uremic syndrome : recurrent phenotypic expression of a patient with MCP gene mutation combined with risk haplotypes. Blood Coagul Fibrinolysis 2018; 30: doi:10.1097

Azevedo A, Faria B, Teixeira C, Carvalho F, Neto G, Santos J, Santos M do C, Oliveira N, Fidalgo T & Calado J. Portuguese Consensus Document Statement in diagnostic and management of atypical hemolytic uremic syndrome. Port J Nephrol Hypertens 2018; 32: 211–32

Coelho SS, Fernandes AR, Soares E, Valério P, Matos B, Romão H, Góis M, Sousa H, Fidalgo T, Natário AS, Barreto C. A new complement factor B mutation associated with crescentic C3 glomerulopathy; a case report. J Nephropathol. 2019;8(3):7-10. DOI: 10.15171/jnp.2019.30

Navarro D, Azevedo A, Sequeira S, Ferreira AC, Carvalho F, Fidalgo T, Vilarinho L, Santos MC, Calado J, Nolasco F. Atypical adult-onset methylmalonic acidemia and homocystinuria presenting as hemolytic uremic syndrome. CEN Case Rep. 2018 May;7(1):73-76. doi: 10.1007/s13730-017-0298-6.

Lopes D, Gomes AM, Cunha C, Pinto CS, Fidalgo T, Fernandes JC. New combined CFH/MCP mutations and a rare clinical course in atypical haemolytic uraemic syndrome. Clin Kidney J. 2015 Dec;8(6):695-7. Clin Kidney J; 8: 695–7. doi: 10.1093/ckj/sfv102.

Borràs N, Orriols G, Batlle J, Pérez-Rodríguez A, Fidalgo T, et al. Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA. Haematologica. 2019 Mar;104(3):587-598. doi: 10.3324/haematol.2018.203166.

Del Orbe Barreto R, Arrizabalaga B, De la Hoz AB, García-Orad Á, Tejada MI, Garcia-Ruiz JC, Fidalgo T, Bento C, Manco L, Ribeiro ML. Detection of new pathogenic mutations in patients with congenital haemolytic anaemia using next-generation sequencing. Int J Lab Hematol 2016; : 1–10.

Manco L, Silva C, Fidalgo T, Martinho P, Sarmento AB, Ribeiro ML. Venous thromboembolism risk associated with ABO, F11 and FGG loci. Blood Coagul Fibrinolysis. 2018 Sep;29(6):528-532. doi: 10.1097/MBC.0000000000000753.

Coucelo M, Caetano G, Sevivas T, Almeida Santos S, Fidalgo T, Bento C, Fortuna M, Duarte M, Menezes C, Ribeiro ML. JAK2V617F allele burden is associated with thrombotic mechanisms activation in polycythemia vera and essential thrombocythemia patients. Int J Hematol. 2014 Jan;99(1):32-40.

McVey JH, Boswell EJ, Takamiya O, Tamagnini G, Valente V, Fidalgo T, Layton M, Tuddenham EG. Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency. Blood. 1998 Aug 1;92(3):920-6.
Research Projects

Congenital coagulopathies, Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uremic syndrome (SHUa).

She has presented in National and International Congresses – 140 communications, 27 invited lectures; She has published 34 scientific articles (Thrombosis and Haemostasis, European Journal of Haematology, Blood Coagulation and Fibrinolysis, Haematologica, among others)

Reviewer of several impact journals.